Severe Hepatitis from Methyldopa

Methyldopa in Treatment of Severe Toxaemia of Pregnancy.

It is known that 50% N20 and 50% 02 mixture is a safe and efficient analgesic for parturient women. The British Oxygen Company have produced single cylinders of premixed gases containing a 50/50 gas and oxygen mixture, which would be ideal for use in midwifery if they could be relied upon to dispense a constant 50/50 mixture. Composition changes in premixed gas and oxygen mixtures have been rep...

A Case of Severe Hepatitis due to Varicella Zoster

Some aspects of the long-term treatment of severe hypertension with methyldopa.

EARLY reports demonstrated the value of methyldopa in the control, and short-term treatment, of hypertension (Irvine, O'Brien & North, 1962; Dollery & Harrington, 1962; Bayliss & HarveySmith, 1962), including the malignant phase (Hamilton & Kopelman, 1963). Subsequently, Johnson et al. (1966) convincingly demonstrated its value in the control of blood pressure of 100 hypertensive subjects over ...

Infections in severe alcoholic hepatitis

Severe alcoholic hepatitis (sAH), defined by a modified discriminant function ≥32, is the most severe form of alcohol-induced liver disease and is associated with a 1-month mortality rate of around 30%. Corticosteroid treatment remains the only therapeutic option that improves short-term survival. Infectious complications, occurring in approximately 50% of patients, are the main causes of death...

Cholestatic jaundice due to methyldopa.

The occurrence of hepatitis in patients taking methyldopa was first described over 10 years ago (Gillespie et al., 1962). Though the degree of bile retention in puiblished case reports varies considerably (Tysell and Knauer, 1971) the clinical picture described is generally indistinguishable from viral hepatitis. When the following patient was seen drug-induced jaundice was suspected but as we ...